I can think of a handful of occasions in which I laughed myself into a complete splinter.
Once, replete in a marching band uniform pepping up our high school football game, Albert Morales and I (drum line, whut?!) started talking about how ridiculous it looks when kids get their heads stuck in the neck of their sweater. Yeah, we were wearing shakos and making fun of kids taking off their sweaters...
More recently, Urian Brown was describing JoJo's Bizarre Adventure (still arguably the most ridiculous manga in comics history) at Gobo in Greenwich Village. You really had to be there, but just imagine someone named Urian Brown acting out this:
and there's a chi-chi juice bar in the background.
In grad school, I almost got expelled for laughing during a speech because the female Korean professor kept being referred to as Ja instead of Ja-Hyun, and my stoner buddy Andy Rodekhor kept muttering, "Ja, Rastafari." (Sigh) College...
Last year Michelle and I rolled up and down Park Avenue laughing after a long night drinking at some Irish pub by Irving Plaza. Michelle told the bartender her name was Anne Ishii and then started sucking his face off. Yes. That's what made us laugh hysterically.
The Hardest Laughter.